Heparin sodium CAS 9041-08-1

Heparin sodium magani ne na anticoagulant, wanda shine abu na mucopolysaccharide.Shi ne gishirin sodium na glucosamine sulfate wanda aka samo daga mucosa na hanji na aladu, shanu da tumaki.tsakiya.Heparin sodium yana da ayyuka na hana haɓakar platelet da lalata, yana hana jujjuyawar fibrinogen zuwa fibrin monomer, hana samuwar thromboplastin da tsayayya da thromboplastin da aka kafa, yana hana jujjuyawar prothrombin zuwa thrombin da antithrombin.

Heparin sodium na iya jinkirta ko hana coagulation jini duka a cikin vitro da in vivo.Tsarin aikinsa yana da rikitarwa sosai kuma yana shafar hanyoyin haɗin gwiwa da yawa a cikin tsarin coagulation.Ayyukansa sune: ①Hana samuwar thromboplastin da aikin thromboplastin, don haka hana prothrombin daga zama thrombin;②A cikin mafi girma da yawa, yana iya hana thrombin da sauran abubuwan coagulation, hana fibrinogen daga zama Fibrin Protein;③ na iya hana tarawa da lalata platelet.Bugu da ƙari, tasirin anticoagulant na sodium heparin yana da alaƙa da mummunan cajin sulfate radical a cikin kwayoyin sa.Abubuwan da aka caje da kyau kamar su protamine ko toluidine blue na iya kawar da mummunan cajin sa, don haka yana iya hana maganin sa.coagulation.Domin heparin na iya kunnawa da sakin lipoprotein lipase a cikin jiki, hydrolyze triglyceride da low-density lipoprotein a cikin chylomicrons, don haka yana da tasirin hypolipidemic.

Ana iya amfani da sodium na Heparin don magance cututtukan thromboembolic mai tsanani, wanda aka watsar da coagulation na intravascular (DIC).A cikin 'yan shekarun nan, an gano heparin yana da tasirin cire lipids na jini.Ciki ko alluran ciki mai zurfi (ko allurar subcutaneous), raka'a 5,000 zuwa 10,000 kowane lokaci.Heparin sodium ba shi da guba kuma yanayin zub da jini na kwatsam shine mafi mahimmancin haɗarin wuce gona da iri na heparin.Ba shi da tasiri a baki, dole ne a yi shi ta hanyar allura.Allurar cikin jiki ko kuma allurar subcutaneous yana da ban haushi, lokaci-lokaci halayen rashin lafiyan na iya faruwa, kuma yawan wuce gona da iri na iya haifar da kama zuciya;lokaci-lokaci asarar gashi da gudawa.Bugu da kari, har yanzu yana iya haifar da karaya ba tare da bata lokaci ba.Yin amfani da dogon lokaci na iya haifar da thrombosis, wanda zai iya zama sakamakon raguwar anticoagulase-III.Heparin sodium an hana shi a cikin marasa lafiya da ciwon jini, hanta mai tsanani da rashin gazawar koda, hauhawar jini mai tsanani, hemophilia, hemorrhage na intracranial, ulcer na ciki, mata masu ciki da bayan haihuwa, ciwace-ciwacen visceral, rauni da tiyata.